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| Name: |
Prof. Adrian Herington |
| Position: |
Acting Executive Dean |
| Qualifications: |
B Sc (Hons), PhD |
| Organisational Area: |
Faculty of Science |
| Research Program: |
Hormone Dependent Cancer |
| Phone: |
+61 7 3138 2205 (PA - Wendy Whittington) |
| Fax: |
+61 7 3138 1534 |
| Email: |
a.herington@qut.edu.au |
| Postal Address: |
Faculty of Science, QUT, GPO Box 2434, Brisbane Qld 4001 |
Teaching Areas
- Hormone Receptors and Signalling
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Areas of Expertise
- Hormone-Dependent Cancer
- Growth Hormone Receptors / Action
- Ghrelin
- Insulin-Like Growth Factors
[Further expertise and media contact]
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Professional Associations
- Endocrine Society (USA)
- The Biochemical Society (UK)
- International Growth Hormone/IGF Research Society
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Current Grants
- NHMRC: Regulation and functional roles of ADAM10 in prostate cancer 2004-2006
- Queensland Cancer Fund: Heterodimerisation of the GHSR and cross-talk with the MAPK (mitogen-activated kinase) signalling pathway in prostate cancer 2005-2006
- Queensland Cancer Fund: The ghrelin axis and an exon 3 deleted ghrelin variant in breast cancer 2006-2007
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Selected Research Projects
- The expression, regulation and function of the growth factor ghrelin and its receptor in hormone dependent cancer.
- Identification, structural and functional studies of novel ghrelin receptors.
- Expression, localization, regulation and functional consequences of ADAMs proteases in prostate cancer models.
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Selected Publications
- Jeffery PL, Herington AC & Chopin LK. The potential autocrine/paracrine roles of ghrelin and its receptor in hormone-dependent cancer, Cytokine & Growth Factor Rev 14: 113-122, 2003.
- McCulloch D, Akl P, Samaratunga H, Herington AC & Odorico DM. Expression of ADAM-10 in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor-I and epidermal growth factor in the prostate cancer cell model LNCaP. Clin Cancer Res 10: 314-323, 2004.
- Veveris-Lowe TL, Lawrence MG, Collard RL, Herington AC, Nicol DL & Clements JA. Prostate-Specific Antigen (PSA) and Kallikrein 4 (hK4) expression is associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in PC-3 prostate cancer cells. Endocrine Related Cancer 12: 617-625 2005.
- Jeffery PL, Murray RE, Yeh AH, McNamara JF, Duncan RP, Stein S, Herington AC & Chopin LK. Expression and function of the ghrelin axis, including a novel proghrelin isoform, in human breast cancer tumours and cell lines. Endocrine Related Cancer 12: 839-850 2005.
- Yeh AH, Jeffery PL, Herington AC & Chopin LK. The role of ghrelin in prostate cancer cell proliferation: ghrelin activates mitogen-activated protein kinase (MAPK) pathways in LNCaP and PC3 prostate cancer cells and a novel preproghrelin isoform in highly expressed in prostate cancer, Clin Cancer Research 11: 8295-303, 2005.
For a curriculum vitae, please download Adrian Herington's CV [PDF 27KB]
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Current Postgraduate Students
| Name |
Project |
| Laura Amorin |
Effects of Ghrelin and Obestatin in Prostate Cancer |
| Peter Cunningham |
Ghrelin Receptor Isoforms in Prostate Cancer Proliferation: Roles of Heterodimerisation and Signaling Cross-Talk |
| Jenny McCarron |
The EphB4 Receptor Tyrosine Kinase in Epithelial Cancers - A Novel Target for Monoclonal Antibody Therapies |
| Vanessa Oakes |
Elucidation of G2 Regulation with Particular Reference to ATR and its Downstream Pathways in Normal and Melanoma Cell Lines |
| Inge Seim |
Potential Post-Transcriptional Regulation of Preproghrelin Protein Expression, and the Hormonal Regulation of the Grhelin Gene in Prostate Cancer |
| Carina Walpole |
The Role of a Novel Over-Expressed Preproghrelin Isoform and the Newly Discovered Preproghrelin Derived Peptide, Obestatin, in Breast Cancer Development |
| Rachel Wight |
The Identification and Characterisation of Novel Biomarkers for Breast Cancer - Including members of the Ghrelin Axis |
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