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| Name: |
Dr Lisa Chopin |
| Position: |
Senior Lecturer |
| Qualifications: |
BVSc (hons) PhD (Qld) MAppSc (Life Sciences) |
| Organisational Area: |
School of Life Sciences |
| Teaching Discipline: |
Medical Sciences |
| Research Program: |
Hormone Dependent Cancer |
| Phone: |
+61 7 3138 6189 |
| Fax: |
+61 7 3138 1534 |
| Email: |
l.chopin@qut.edu.au |
| Postal Address: |
School of Life Sciences, QUT, GPO Box 2434, Brisbane Qld 4001 |
Teaching Areas
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Areas of Expertise
- breast cancer
- prostate cancer
- ghrelin
- hormone dependent cancer
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Professional Associations
- Member of Endocrine Society of Australia
- Registered Veterinary surgeon, Veterinary Surgeon's Board Qld
- Member, Growth hormone research society
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Current Grants
- Queensland Cancer Fund (2005-2006)Chopin and Herington - Heterodimerisation of the GHSR and cross-talk with the MAPK (Mitogen activated kinase) signalling pathway in prostate cancer.
- Queensland Cancer Fund (2006-2007)Chopin, Herington and Harris - The role of autocrine ghrelin, a growth hormone releasing peptide, and a novel preproghrelin variant in breast cancer
- Queensland Cancer Fund (2007-2008) Chopin, Herington and Harris - The exon 3 deleted preproghrelin isoform is overexpressed in prostate cancer, stimulates cell proliferation, but does not express obestatin, a natural peptide derived from the ghrelin gene that opposes the action of ghrelin
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Selected Research Projects
- The role of the ghrelin axis in breast, ovarian and prostate cancer
- The ghrelin axis in inflammatory bowel disease and colon cancer
- Ghrelin signalling
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Selected Publications
- PL Jeffery, A. Yeh, AC Herington, LK Chopin (2005) The role of ghrelin in prostate cancer cell proliferation: ghrelin activates mitogen-activated protein kinase (MAPK) pathways in LNCaP and PC3 prostate cancer cells and a novel preproghrelin isoform is highly expressed in prostate cancer. Clinical Cancer Research 11:8295-303
- PL Jeffery, RP Duncan, AC Herington A. Yeh, R. Jaskolski, DS Hammond and LK Chopin (2005) Expression of the ghrelin axis in the mouse: an exon 4 deleted mouse proghrelin variant encodes a novel C terminal peptide. Endocrinology 146(1):432-40
- PL Jeffery, RE. Wight, RP Duncan, A. Yeh, JF McNamara, AC Herington, LK Chopin (2005) Expression of components of the ghrelin/growth hormone secretagogue receptor axis in breast cancer cell lines and in breast cancer histopathological specimens. Endocrine Cancer Research 12:839-850
- PL Jeffery, AC Herington and LK Chopin (2003) Ghrelin and its receptor, the growth hormone secretagogue receptor (GHS-R) in cancer. Cytokine and Growth Factor Reviews 14:113-122
- PL Jeffery, AC Herington and LK Chopin (2002) The co-expression of the growth hormone secretagogue receptor and its endogenous ligand, ghrelin, in prostate cancer cell lines. Journal of Endocrinology 172:R7-R11
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Current Postgraduate Students
| Name |
Project |
| Laura Amorim |
the role of the ghrelin axis in the cell biology of prostate cancer |
| Peter Cunningham |
ghrelin signaling in prostate cancer |
| Inge Seim |
ghrelin isoforms and their role and expression in breast and prostate cancer |
| Carina Walpole |
the role of the ghrelin axis in the cell biology of breast and ovarian cancer |
| Rachael Wight |
the role of the ghrelin axis in breast cancer and biomarker discovery for breast cancer |
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